She added, "You always have the right to change her mind".
"She loves this country and would like to be of service in some way".
And Trump showed that voters are tired of traditional candidates.
Critics said Ms Trump's support for the president was incompatible with her endorsement of Ms Winfrey's Time's Up campaign.
"I don't, I don't", the US billionaire media mogul reportedly said backstage at the Globes when asked if she planned to run. "Listen, she writes her 'What I Know for Sure' column every month in the magazine. If I can't get Oprah, I'd like someone like her".
And Kirsten Gillibrand, for whom Al Franken was subjected to ritual sacrifice on the altar of her presidential ambitions? "I think it's a very, very intriguing idea myself".
This isn't the first time Winfrey's name has been tossed into the political ring. "She has provided inspiration for millions of women to improve their lives, go back to school, learn to read, and take responsibility for themselves". Hillary Clinton - the policy wonk who couldn't crystallize a compelling message for middle America - needed Oprah as a key communications strategist when it counted.
"People need to have hope", said Ray Buckley, chairman of the New Hampshire Democratic Party, who encouraged the idea of an Oprah run. "I don't think she's going to run". "Just saw @Oprah's empowering and inspiring speech at last night's #GoldenGlobes".
Trump's job approval rating sat at just 32 per cent in December, according to an Associated Press-NORC poll.
Winfrey is popular. She's empathetic. He has also been accused by multiple women of sexual misconduct, though he has vehemently denied the allegations.
However, even if this were true, it still would have been long before Weinstein was outed and ostracized as an alleged serial predator.
Immediately after her speech, the hashtag #Oprah2020 began trending on Twitter. I absolutely believe King when she says that Winfrey is not "actively considering" the race.
Late-night show host Jimmy Kimmel said Monday that he preferred Winfrey to Trump. She will heal them, she will cleanse them, and they will love for it. Will she run for president?
Winfrey's presidential history also extends to the previous administration. At that time, he was known mostly as a prolific producer who had worked with a number of well-respected actors and actresses. She really did want to speak to young girls around the country.