Romelu Lukaku and Marcus Rashford scored the goals for United.
Unbeaten Manchester City can move into its biggest lead of the season 11 points with a win at second-place Manchester United.
With European heavyweights like Bayern Munich, Chelsea, Real Madrid and Juventus in pot two, there are guaranteed to be some blockbuster clashes in the second round. Five managers have already been fired this season.
"It's another step forward in broadcast innovation that will give BT Sport the best possible viewing experience and shows BT Sport continues its commitment to be at the heart of this", BT Sport COO Jamie Hindhaugh said in a statement.
But in a year where he will likely win the Ballon d'Or, Ronaldo grabbed one record for himself.
"Their goalkeeper was on fire".
Manchester United manager Jose Mourinho said: "I'm really happy because we don't want to qualify with a defeat", he said after United made the last 16 for the first time since 2013-14. The Real Madrid legend became the first man to score in every single Champions League group stage game - hitting nine in the process. This one was not his most significant, but the style in which he achieved it was typical.
By Joseph Wilson in Barcelona.
Bayern defender Jerome Boateng will face his brother, Kevin-Price Boateng.
By Ciaran Fahey in Berlin. Premier League teams were in seven finals from 2005 to 2012 but have not been back since. Inter is one point ahead of Napoli and Juventus is one point further back.
For the first time ever, five English teams have qualified for the knockout stages of the Champions League.
Atletico have pedigree in the tournament. "For us it's very important to look at ourselves".
By Andrew Dampf in Rome.
We will remind that on Wednesday, December 6, is the only representative of Ukraine Donetsk "Shakhtar" will try to win a ticket to the playoffs of the Champions League: our website holds online text of "Shakhtar" - "Manchester city".
The Red Devils finished as winners of their group, with their final fixture being a 2-1 triumph over CSKA Moscow at Old Trafford. The games decided the fates of many teams.