Muguruza, 23, playing under the watchful eye of Juan Carlos I of Spain sitting in the Royal Box, took the 10th seed Williams' game apart piece-by-piece in the 77-minute match.
His victory over long-time rival Rafael Nadal at the Australian Open in January marked the beginning of his comeback at the ripe old age of 35 after a five-year title drought.
She had also been runner-up to Serena Williams in the 2015 Wimbledon final. And it was her experience that proved critical. This seemed destined to be an afternoon full of screaming winners, a showcase for power tennis on the sport's greatest stage. With the roof closed over Centre Court because of a mizzly rain, the sound of their struck forehands was near concussive. And she won just six points on serve in the second set. She leads the second set 4-0.
Claire Liu became the first American in 25 years to win the junior title at Wimbledon. Remarkably at the age of 37, Venus has more Grand Slam victories in 2017 than any other woman.
Garbine Muguruza already knew how it feels to lose to a Williams in the Wimbledon final.
And the underlying message for her regular coach was laced with humour. If you like your tennis this way, you tend to talk about the improved depth of the women's field, about the excitement of surprise, about "openness".
"No, definitely not. I was talking with him every day". It wasn't the perfect bow in the final chapter of her career.
Muguruza broke serve on a second break point in the 11th game when Williams sailed a forehand long, and from that point on Muguruza was in complete charge of the match. Angelique Kerber was unable to handle the pressure of being No. 1 and is going to drop this week.
"She just dug in there and managed to play better".
Remarkably, of her four tour-level titles, two are now Grand Slams. Others scuttled quietly to the sides of the court, landing wide.
But she meant no disrespect in highlighting the age gap - quite the opposite.
"For me, it was a challenge to have her, growing up watching her play".
This had been expected to be a close, tight match, and for most of the first set, it lived up to its billing. And I like Cilic, I have to say seriously. She lost 7-5, 6-0 to Garbine Muguruza in the final. Both women came to it playing superbly. And finally, last month, Williams posed naked for a stunning Vanity Fair cover shoot, showing off her growing baby bump.
"I think today, I played well".
Instead this was a forgettable battle of attrition.
Since winning her maiden Grand Slam title at the French Open last year, Muguruza had endured something of a sophomore slump as her ranking dropped out of the top 10.
I certainly can't see Cilic winning the final from the baseline. I like to think it´s working for me.
Success! An email has been sent with a link to confirm list signup. I don't want to just get to a final.